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More World-wide Praise for Colloidal Silver from Clinical Researchers
Canadian Researchers: Ionic Silver is a Safe, Non-Toxic Bacterial Disinfectant
“Silver is a disinfectant for non-spore forming bacteria at concentrations about 1000 times lower than the levels at which it is toxic to mammalian life. …The ionic form of silver is necessary.”
-British Columbia Ministry of Environment, Ambient Water Quality Criteria for Silver, Environmental Protection Department, February 19, 1996
Australian Researchers: Colloidal Silver Safely Stops Staphylococcus aureus Sinus Infections
“ In the safety study, normal saline (control) and 30ppm colloidal silver solution (test) was used to flush the frontal sinuses for 14 days in 8 sheep (4 sheep each). In the efficacy study, following frontal sinus infection with Staphylococcus aureus, sheep were treated with either control saline or topical silver solution of varying concentrations (30 ppm/20 ppm/10 ppm/5 ppm) for 5 days, with 4 sheep in each group. Sheep treated with colloidal silver showed a significant decrease in biofilm biomass compared to saline control. Although average blood silver levels were higher in the treated groups compared to controls, blood counts and biochemical parameters were normal. Histology and ciliary structure analysis did not show any difference between control and treatment groups …Conclusion: Topical colloidal silver solution has effective antibiofilm activity in Staphylococcus aureus CRS in a sheep model and appears safe.”
“Topical colloidal silver as an antibiofilm agent in a Staphylococcus aureus chronic rhinosinusitis sheep model”
International Forum of Allergy & Rhinology; The Queen Elizabeth Hospital, Department of Surgery, University of Adelaide, Adelaide, Australia
Korean Researchers: Nanosilver Is Effective Against Pathogenic Fungal Microbes
“Many studies have shown the antimicrobial effects of nanosilver, but the effects of nanosilver against fungal pathogens of the skin, including clinical isolates of T. mentagrophytes and Candida species are mostly unknown. The primary significance of this study is the observation that nanosilver can inhibit the growth of dermatophytes, which cause superficial fungal infections. Nanosilver also exhibited potent antifungal effects, probably through destruction of membrane integrity. To the author’s knowledge, this is the first study to apply nanosilver successfully to dermatophytes and pathogenic fungal strains. Secondly, the fact that preparation method of nanosilver described here is cost-effective is also of importance. Therefore, it can be expected that nanosilver may have potential as an anti-infective agent for human fungal diseases “
– The Silver Nanoparticle (Nano-Ag): a New Model for Antifungal Agents, Dong Gun Lee School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Republic of Korea
Japanese Researchers: Silver Nanoparticles Demonstrate Excellent Antibacterial Activity With Low Toxicity for Humans and Animals
“…It is well known that silver exhibits potent antibacterial properties with low toxicity for humans and animals, by comparison with other metals. Many researchers have recently reported that silver nanoparticles demonstrate excellent antibacterial activity.”
– On-Paper Synthesis of Silver Nanoparticles for Antibacterial Applications, Hirotaka Koga and Takuya Kitaoka, Kyushu University, Japan
Mexican Researchers: Silver Nanoparticles Beat Drug-Resistant Super-Pathogens
“The data presented here prove that silver nanoparticles are effective bactericidal agents regardless of the drug-resistance mechanisms that exist in multidrug-resistant P. aeruginosa, ampicillin-resistant E. coli O157:H7 and erythromycin-resistant S. pyogenes and show the importance of silver nanoparticles in the nosocomial and community environment. Therefore, silver nanoparticles can be recommended as an effective broad-spectrum bactericidal agent.”
-“Bactericidal Effect of Silver Nanoparticles Against Multi-drug Resistant Bacteria,”
World Journal of Microbiology, Volume 26, Number 4, 615-621, DOI: 10.1007/s11274-009-0211-3) April 10, 2009
Pakistani Researchers: Silver Ions Are Toxic to Infectious Microbes Without Harming Normal Cells
“Silver is non-toxic, safe inorganic antibacterial agent being used for centuries and is capable of killing about 650 microorganisms that cause disease. Silver has been described as being ‘oligodynamic’, that is, its ions are capable of causing a bacteriostatic (growth inhibition) or even a bactericidal (antibacterial) impact. Therefore, it has the ability to exert a bactericidal effect at minute concentrations. It has a significant potential for a wide range of biological applications such as antibacterial agents for antibiotic resistant bacteria, preventing infections, healing wounds and anti-inflammatory. Silver ions (Ag+) and its compounds are highly toxic to microorganisms exhibiting strong biocidal effects on many species of bacteria but have a low toxicity toward animal cells “
– Muhammad Raffi, Synthesis and Characterisation of Metal Nanoparticles, Department of Chemical and Materials Engineering, Pakistan Institute of Engineering and Applied Sciences
Scandinavian Researchers: Colloidal Silver Spray Cures Leg Ulcers
“Study Synopsis: Sixteen patients with leg ulcers were treated with a colloidal silver spray. The solution was applied once daily for the first few days, then twice weekly. The infection subsided in all cases. After instruction, patients performed the therapy at home without supervision. No discomfort or side effects were observed. There was no persistent discolouration of the skin that could be attributed to silver. “In all cases the infection subsided.”
– Haeger, Knut. Preoperative treatment of leg ulcers with silver spray and aluminium foil. Acta Chirurgica Scandinavica, 125, 32-41.
Czech Researchers: Silver Nanoparticles Beat Multi-Drug-Resistant Bacterial Strains
“…silver particles with a narrow size distribution with an average size of 25 nm showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multi-resistant strains such as methicillin-resistant Staphylococcus aureus. Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 μg/mL Ag) gave antibacterial performance.”
-Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity; Department of Physical Chemistry, Palacký University, Svobody 26, 771 46 Olomouc, Czech Republic, Department of Microbiology, Faculty of Medicine, Palacký University, Czech Republic
Turkish Researchers: Silver Nanoparticles Effective Against Disease-Causing Bacteria and Candida Fungus
“Silver or silver ions have long been known to possess strong inhibitory and bactericidal effects, as well as a broad spectrum of antimicrobial activities…In this study, the antimicrobial activity of colloidal silver nanoparticles prepared by the Sol-Gen method was investigated [against] test microorganisms Escherichia coli, Staphylococcus aureus, Candida albicans, Bacillus subtilis, Salmonella typhimurium, Pseudomonas aeruginosa and Klebsiella pneumoniae. It was found that the silver nanoparticles inhibited the growth and multiplication of the tested microorganisms, including the fungus C. albicans. The antimicrobial activity was observed against all tested microorganisms at a very low concentration of 2-4 μg/ml of nano silver.”
“Antimicrobial Activity Of Colloidal Silver Nanoparticles Prepared By Sol-Gel Method.”
Digest Journal of Nanomaterials and Biostructures, Metallurgical and Material Science Engineering Department at Dokuz Eylul University, Turkey
African Researchers: Silver Nanoparticles Reduce the Growth of Melanoma Tumours and Breast Cancer Cells
“Previously, we reported the cytotoxic effect of colloidal silver on MCF-7 breast cancer cell line. However, there is scarce information on its anti-tumour potential. The aim of this study was to evaluate the anti-tumoural activity of colloidal silver or silver nanoparticles (AgNPs) in a B16F10 melanoma mice model. In vitro, B16F10 cells were treated with different concentrations of colloidal silver or silver nanoparticles and cell viability was evaluated by MTT method, both treatments had cytotoxic effects against B16F10 cell line. In vivo, B16F10 melanoma cells were implanted in six weeks old C57BL/6 mice. About 8 days after cells injection, the subcutaneous treatments were started with colloidal silver or silver nanoparticles, tumour volume and tumour weight were evaluated and the difference of treated groups and control demonstrated that melanoma tumour growth was significantly decreased. Our results suggest that colloidal silver or silver nanoparticles could be useful as an anti-proliferative drug, inducing an impairment of tumoural growth.”
– African Journal of Microbiology Research, May 2013, “Potential of colloidal or silver nanoparticles to reduce the growth of B16F10 melanoma tumours”
